New sensitizers and rapid monitoring of their photodynamic activity

Nadezgda L. Torshina; Anna M. Posypanova; Anna I. Volkova

doi:10.1117/12.237546

2 April 1996 New sensitizers and rapid monitoring of their photodynamic activity

Nadezgda L. Torshina, Anna M. Posypanova, Anna I. Volkova

Proceedings Volume 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V; (1996) https://doi.org/10.1117/12.237546
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

At present, there are lots and lots of chemical compounds that are, to a certain extent, photodynamically active. Therefore, the task of carrying out the expressive screening of such compounds has been raised sharply enough. The primary screening in vitro of compounds, with the help of biological liquids, is notable for quickness and cheapness at the same time, it is possible to determine the comparative characteristics of compounds by their photodynamical activity. Decomposition of albumins of a mixture of photosensitizer and biological liquid when irradiating with light is the basis of this method. Efficiency of decomposition of components of biological liquids is determined using biochemical reactions (e.g., those for determining the total albumins or blood hemoglobin). Subsequently, with a sufficient efficiency of a photosensitizer, it will be possible to carry out a study in vivo, with the purpose of establishing accumulation of preparations in tumor.

Citation Download Citation

Nadezgda L. Torshina, Anna M. Posypanova, and Anna I. Volkova "New sensitizers and rapid monitoring of their photodynamic activity", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237546

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