Photodynamic drug detection system for measurement of drug uptake

Winston Ho; Peter W. Low; Kalin Spariosu

doi:10.1117/12.237524

2 April 1996 Photodynamic drug detection system for measurement of drug uptake

Winston Ho, Peter W. Low, Kalin Spariosu

Proceedings Volume 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V; (1996) https://doi.org/10.1117/12.237524
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

It is known that if the drug uptake by a tumor is below the required concentration the efficacy of PDT can be significantly reduced. There is, therefore, a need for a photodynamic drug detection (PD³) system to be used with PDT to monitor the drug concentration in tissue in real time and noninvasively. The system developed integrates laser, a fiber optic probe, and an optical detector to detect photodynamic drugs (Photofrin II, Protoporphyrin IX, and BPD). A series of drug concentrations was measured based on the detection of diffusely fluorescence photons. The fluorescence peak at 680 nm is suggested for intensity measurement. The effect of fluorescence reabsorption was observed when using high concentration Photofrin solutions. When PD³ is used in conjunction with monitoring through an endoscope, the system offers spectral information (displayed on a computer monitor) in addition to the conventional image (displayed on an endoscope monitor).

Citation Download Citation

Winston Ho, Peter W. Low, and Kalin Spariosu "Photodynamic drug detection system for measurement of drug uptake", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237524

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