Photodynamic therapy in Barrett's esophagus: review of current results

Masoud Panjehpour; Bergein F. Overholt M.D.

doi:10.1117/12.237536

2 April 1996 Photodynamic therapy in Barrett's esophagus: review of current results

Masoud Panjehpour, Bergein F. Overholt M.D.

Proceedings Volume 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V; (1996) https://doi.org/10.1117/12.237536
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Photodynamic therapy has been established as an alternative treatment for patients with Barrett's esophagus with dysplasia or early superficial cancer. Twenty-three patients have been treated and followed for 6 - 54 months. Twenty-one patients had high grade dysplasia and 2 had low grade dysplasia. Ten patients had early cancer (Tis-T1) and 1 had T2 cancer. All patients were maintained on omeprazole after treatment. Three separate PDT treatments were required in 2 patients, 2 in 5 patients and 1 in 16. Dysplasia and carcinoma were eliminated in all. Seventy-five to eighty percent of Barrette's mucosa was replaced by squamous epithelium. One patient developed a new carcinoma in an area of dysplasia treated 3 months earlier and was retreated successfully. Two patients developed new areas of dysplasia in untreated segments of the Barrett's esophagus, requiring a separate treatment. Twelve patients developed strictures, all responding well to dilatation.

Citation Download Citation

Masoud Panjehpour and Bergein F. Overholt M.D. "Photodynamic therapy in Barrett's esophagus: review of current results", Proc. SPIE 2675, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, (2 April 1996); https://doi.org/10.1117/12.237536

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