Tissue diagnostics by depth profiling of optical characteristics using broadband fiber optic interferometry

Robert Splinter; Faramarz Farahi; M. Yasin Akhtar Raja; Robert H. Svenson

doi:10.1117/12.231680

9 February 1996 Tissue diagnostics by depth profiling of optical characteristics using broadband fiber optic interferometry

Robert Splinter, Faramarz Farahi, M. Yasin Akhtar Raja, Robert H. Svenson

Author Affiliations +

Proceedings Volume 2732, CIS Selected Papers: Coherence-Domain Methods in Biomedical Optics; (1996) https://doi.org/10.1117/12.231680
Event: CIS Selected Papers: Coherence Domain Methods in Biomedical Optics, 1995, Saratov, Russian Federation

Abstract

A broadband interferometer is used to acquire scattered light as a function of depth in biological media. The `tissue-light-signature' that is obtained by this depth scan can be correlated with the computer simulated light distributions for well defined tissue parameters, and wavelengths of specific interest. In theory, the collimated irradiation of heart tissue, by low coherence light will generate a statistically significant different light signature for respective myocardial tissues, and pathological tissue conditions. Interferometric axial scanning of in vitro myocardial tissues confirmed the statistically significant difference between normal, coagulated myocardium, and aneurysm at the 790 nm wavelength. The scanning depth however is presented limited by the intensity of the illumination and the choice of detection scheme. Identification of the local optical characteristics as a function of depth directly underneath the target zone will provide discrimination between healthy and pathological conditions in addition to real time assessment of laser dosimetry. Theoretically the scanning depth is limited to a maximum of 4 mm. The beam profile of the irradiation source significantly affects the ability to distinguish between certain tissues. Broadband interferometric axial tissue scanning, will provide a tool for an accurate light energy delivery guided by the desired outcome, while being able to verify the appropriate target location, in real time.

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Robert Splinter, Faramarz Farahi, M. Yasin Akhtar Raja, and Robert H. Svenson "Tissue diagnostics by depth profiling of optical characteristics using broadband fiber optic interferometry", Proc. SPIE 2732, CIS Selected Papers: Coherence-Domain Methods in Biomedical Optics, (9 February 1996); https://doi.org/10.1117/12.231680

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