Is smaller better?--Scaling of characteristics with size of fiber-optic chemical and biochemical sensors

Raoul Kopelman; Sunil Dourado

doi:10.1117/12.260577

10 December 1996 Is smaller better?--Scaling of characteristics with size of fiber-optic chemical and biochemical sensors

Raoul Kopelman, Sunil Dourado

Author Affiliations +

Proceedings Volume 2836, Chemical, Biochemical, and Environmental Fiber Sensors VIII; (1996) https://doi.org/10.1117/12.260577
Event: SPIE's 1996 International Symposium on Optical Science, Engineering, and Instrumentation, 1996, Denver, CO, United States

Abstract

Micron and submicron fiber-optic chemical and biochemical sensors have been developed recently in our laboratory. Here we give a theoretical discussion, based on pragmatic modes of operation, of the advantages and disadvantages of optode miniaturization. In most instances we present explicit functional dependences of specific optode characteristics on the optode radius (r). For instance, the absolute detection limit decreases with r³ (good the response time reduces with r² (good noise ratio decreases with r (bad our standard working conditions. Other features that improve with down-sizing include sample volume, sensitivity, invasiveness, spatial resolution, enzyme activity, heating of sensor and/or sample, toxicity and materials cost. Features that may worsen include fluorophore leaching and photodamage to sensor and/or sample. Methods for overcoming these disadvantages make use of the shorter response times of small optodes and forward optical signal collection with small samples (utilizing standard lab microscopes). We refer to the ultimate goal of non-destructive single molecule detection and imaging.

Citation Download Citation

Raoul Kopelman and Sunil Dourado "Is smaller better?--Scaling of characteristics with size of fiber-optic chemical and biochemical sensors", Proc. SPIE 2836, Chemical, Biochemical, and Environmental Fiber Sensors VIII, (10 December 1996); https://doi.org/10.1117/12.260577

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