Research in boron neutron capture synovectomy

E. Binello; S. Shortkroff; A. Jones; C. Viveiros; A. Ly; C. B. Sledge; A. Davison; Ruth E. Shefer; Jacquelyn C. Yanch

doi:10.1117/12.267854

27 February 1997 Research in boron neutron capture synovectomy

E. Binello, S. Shortkroff, A. Jones, C. Viveiros, A. Ly, C. B. Sledge, A. Davison, Ruth E. Shefer, Jacquelyn C. Yanch

Proceedings Volume 2867, International Conference Neutrons in Research and Industry; (1997) https://doi.org/10.1117/12.267854
Event: Fifth International Conference on Applications of Nuclear Techniques: Neutrons in Research and Industry, 1996, Crete, Greece

Abstract

Boron Neutron Capture Synovectomy (BNCS) is a novel application of the ¹⁰B(n, (alpha) )⁷Li reaction for the treatment of Rheumatoid Arthritis. This potential treatment modality is in its developmental stages; in this paper results of research in two aspects of BNCS are presented. First, quantification of ¹⁰B-uptake in samples of human arthritic tissue by Prompt Gamma Neutron Activation Analysis is presented. ¹⁰B concentrations from 1625 to 2726 ppm are readily achieved. Second, ideal neutron beam studies have been undertaken and indicate that neutrons from thermal energies to 1 keV are useful for BNCS. This information is of use in designing practical therapy beams should this treatment modality be realized.

Citation Download Citation

E. Binello, S. Shortkroff, A. Jones, C. Viveiros, A. Ly, C. B. Sledge, A. Davison, Ruth E. Shefer, and Jacquelyn C. Yanch "Research in boron neutron capture synovectomy", Proc. SPIE 2867, International Conference Neutrons in Research and Industry, (27 February 1997); https://doi.org/10.1117/12.267854

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