Treatment of laser-induced retinal injuries by neuroprotection

Yoram Solberg M.D.; Mordechai Rosner M.D.; Michael Belkin M.D.

doi:10.1117/12.275238

2 May 1997 Treatment of laser-induced retinal injuries by neuroprotection

Yoram Solberg M.D., Mordechai Rosner M.D., Michael Belkin M.D.

Proceedings Volume 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment; (1997) https://doi.org/10.1117/12.275238
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Retinal laser photocoagulation treatments are often complicated with immediate side-effect of visual impairment. To determine whether glutamate-receptor blockers can serve as adjuvant neuroprotective therapy, we examined the effect of MK-801, an NMDA-receptor antagonist, on laser-induced retinal injury in a rat model. Argon laser retinal lesions were created in the retina of 36 DA rats. Treatment with intraperitoneal injections of MK-801 or saline was started immediately after the laser photocoagulation. The animals were sacrificed after 3, 20 or 60 days and the retinal lesions were evaluated histologically and morphometrically. Photoreceptor-cell loss was significantly smaller in MK-801-treated rats than controls. The proliferative membrane composed of retinal pigment epithelial cells which was seen at the base of the lesion in control retinas, was smaller in the MK-801-treated retinas. MK-801 exhibited neuroprotective and anti-proliferative properties in the retina. Glutamate-receptor blockers should be further investigated for serving as adjuvant therapy to retinal photocoagulation treatments.

Citation Download Citation

Yoram Solberg M.D., Mordechai Rosner M.D., and Michael Belkin M.D. "Treatment of laser-induced retinal injuries by neuroprotection", Proc. SPIE 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment, (2 May 1997); https://doi.org/10.1117/12.275238

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available