PRM/NIR sensor for brain hematoma detection and oxygenation monitoring

Liu Zheng; Hyo Sang Lee; Sandor Lokos; Jin Kim; Daniel F. Hanley; David A. Wilson

doi:10.1117/12.275537

16 June 1997 PRM/NIR sensor for brain hematoma detection and oxygenation monitoring

Liu Zheng, Hyo Sang Lee, Sandor Lokos, Jin Kim, Daniel F. Hanley, David A. Wilson

Proceedings Volume 2976, Biomedical Sensing, Imaging, and Tracking Technologies II; (1997) https://doi.org/10.1117/12.275537
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

The pseudo-random modulation/near IR sensor (PRM/NIR Sensor) is a low cost portable system designed for time-resolved tissue diagnosis, especially hematoma detection in the emergency care facility. The sensor consists of a personal computer and a hardware unit enclosed in a box of size 37 X 37 X 31 cm³ and of weight less than 10 kg. Two pseudo-random modulated diode lasers emitting at 670 nm and 810 nm are used in the sensor as light sources. The sensor can be operated either in a single wavelength mode or a true differential mode. Optical fiber bundles are used for convenient light delivery and color filters are used to reject room light. Based on a proprietary resolution- enhancement correlation technique, the system achieves a time resolution better than 40 ps with a PRM modulation speed of 200 MHz and a sampling rate of 1-10 Gs/s. Using the prototype sensor, phantom experiments have been conducted to study the feasibility of the sensor. Brain's optical properties are simulated with solutions of intralipid and ink. Hematomas are simulated with bags of paint and hemoglobin immersed in the solution of varies sizes, depths, and orientations. Effects of human skull and hair are studied experimentally. In animal experiment, the sensor was used to monitor the cerebral oxygenation change due to hypercapnia, hypoxia, and hyperventilation. Good correlations were found between NIR measurement parameters and physiological changes induced to the animals.

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Liu Zheng, Hyo Sang Lee, Sandor Lokos, Jin Kim, Daniel F. Hanley, and David A. Wilson "PRM/NIR sensor for brain hematoma detection and oxygenation monitoring", Proc. SPIE 2976, Biomedical Sensing, Imaging, and Tracking Technologies II, (16 June 1997); https://doi.org/10.1117/12.275537

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KEYWORDS

Sensors

Brain

Modulation

Picosecond phenomena

Skull

Near infrared

Signal detection

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