Detection of cancer by means of infrared spectroscopy

Yitzhak Weissman; Aharon Bonstein; Tania Babushkin; Zvi Malik; Arie Ornstein

doi:10.1117/12.281374

22 September 1997 Detection of cancer by means of infrared spectroscopy

Yitzhak Weissman, Aharon Bonstein, Tania Babushkin, Zvi Malik, Arie Ornstein

Proceedings Volume 3110, 10th Meeting on Optical Engineering in Israel; (1997) https://doi.org/10.1117/12.281374
Event: 10th Meeting on Optical Engineering in Israel, 1997, Jerusalem, Israel

Abstract

We have measured the mid-infrared spectra of several tissues in a malignant and normal state, using the ATR sampling method. The aim of the experiments was to detect cancer signatures that were discovered earlier using other sampling methods. The ATR method is particularly attractive for medical applications because it can be used in-vivo, and because it requires minimal sample preparation. We have succeeded to detect a significant signature in only one of the five spectral bands that were examined. This signature is attributed to the PO₂^- symmetric stretching of the nucleic acids phosphodiester groups, and is located in the vicinity of 1082 cm^-1. The signature consists of a shift in the maximum absorption peak by 3 cm^-1. The measured data is in good agreement with the published data. This result can lead to real-time tumor mapping during surgery and in-vivo cancer diagnosis with fiber-optic ATR probes.

Citation Download Citation

Yitzhak Weissman, Aharon Bonstein, Tania Babushkin, Zvi Malik, and Arie Ornstein "Detection of cancer by means of infrared spectroscopy", Proc. SPIE 3110, 10th Meeting on Optical Engineering in Israel, (22 September 1997); https://doi.org/10.1117/12.281374

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