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29 December 1997 Collagen-gel-induced resistance of overlying keratinocyte cultures to photosensitization
John C. Katsantonis, Savas K. Georgiou, Mary G. Providaki, John G. Vlahonikolis, Andronicki D. Tosca
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Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297792
Event: BiOS Europe '97, 1997, San Remo, Italy
Abstract
In the present study it was found that human keratinocytes grown on collagen substrate, exhibited increased resistance to the hematoprophyrin-mediated photodynamic treatment, in comparison to keratinocytes grown on Petri dishes without collagen. Interestingly, no protection was afforded by the collagen gel to the cells in the corresponding control ('hematoprophyrin only' and 'light only') experiments. This observation was found to be independent of light dose and drug concentration, and the relative degree of resistance was the same for both normal and malignant cells. The degree of keratinocyte resistance was found to be closely related to the duration of cell attachment on the collagen substrate. These results are indicative of an active interference of collagen gel with the cellular evolution of the photodynamic phenomenon and they are also suggestive of variation in the photodynamic treatment efficacy according to the cellular environment.
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John C. Katsantonis, Savas K. Georgiou, Mary G. Providaki, John G. Vlahonikolis, and Andronicki D. Tosca "Collagen-gel-induced resistance of overlying keratinocyte cultures to photosensitization", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297792
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KEYWORDS
Resistance
Collagen
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