Improvement of cancer PDT using sulphophthalocyanine and sodium ascorbate

Oleg L. Kalija; Gennadii A. Meerovich; Nadezgda L. Torshina; Eugenia A. Kogan; Victor B. Loschenov; Eugeny A. Lukyanets; Boris Ya. Kogan; Alexander V. Butenin; Georgy N. Vorozhtsov; Sergei G. Kuzmin; Anna I. Volkova; Anna M. Posypanova

doi:10.1117/12.297800

29 December 1997 Improvement of cancer PDT using sulphophthalocyanine and sodium ascorbate

Oleg L. Kalija, Gennadii A. Meerovich, Nadezgda L. Torshina, Eugenia A. Kogan, Victor B. Loschenov, Eugeny A. Lukyanets, Boris Ya. Kogan, Alexander V. Butenin, Georgy N. Vorozhtsov, Sergei G. Kuzmin, Anna I. Volkova, Anna M. Posypanova

Author Affiliations +

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297800
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

It is well known that sulphophthalocyanines induce in process of PDT photochemical reaction of II type with generation of cytotoxic agent -- singlet oxygen. The combination of phthalocyanine and exogenic reductant -- sodium ascorbate may also induce other reactions, involving the formation of free radicals, and thus intensify the antitumor effect. The mechanism of action of the ascorbate may be connected also with the direct tumor cells damage (apoptosis) and with the stimulation of antiblastome resistance. We conducted the experimental study on 150 white mice with Erlich carcinoma. Macroscopic and microscopic data showed that ascorbate significantly increases the effect of PDT in comparison with control group due to the higher tumor damage, inhibition of its growth and stimulation of antitumor desmoplastic reaction.

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Oleg L. Kalija, Gennadii A. Meerovich, Nadezgda L. Torshina, Eugenia A. Kogan, Victor B. Loschenov, Eugeny A. Lukyanets, Boris Ya. Kogan, Alexander V. Butenin, Georgy N. Vorozhtsov, Sergei G. Kuzmin, Anna I. Volkova, and Anna M. Posypanova "Improvement of cancer PDT using sulphophthalocyanine and sodium ascorbate", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297800

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