Two-dimensional birefringence imaging in biological tissue using polarization-sensitive optical coherence tomography

Johannes F. de Boer; Thomas E. Milner; Martin J. C. van Gemert; J. Stuart Nelson M.D.

doi:10.1117/12.297943

13 January 1998 Two-dimensional birefringence imaging in biological tissue using polarization-sensitive optical coherence tomography

Johannes F. de Boer, Thomas E. Milner, Martin J. C. van Gemert, J. Stuart Nelson M.D.

Author Affiliations +

Proceedings Volume 3196, Optical and Imaging Techniques for Biomonitoring III; (1998) https://doi.org/10.1117/12.297943
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

Using a polarization sensitive Michelson interferometer, we measure 2D images of optical birefringence in bovine tendon as a function of depth with a technique known as optical coherence tomography (OCT). Detection of the polarization state of the signal, formed by interference of backscattered light from the sample and a mirror in the reference arm, gives the optical phase delay between light that has propagated along the fast and slow axes of the birefringent tendon. Images showing the change in birefringence in response to laser irradiation are presented. The technique allows rapid non-contact investigation of tissue structural properties through 2D imaging of birefringence.

Citation Download Citation

Johannes F. de Boer, Thomas E. Milner, Martin J. C. van Gemert, and J. Stuart Nelson M.D. "Two-dimensional birefringence imaging in biological tissue using polarization-sensitive optical coherence tomography", Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); https://doi.org/10.1117/12.297943

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