Electrical impedance imaging for tissue monitoring and assessment during thermal therapy

Keith D. Paulsen; Alex Hartov; Kendra Sunshine Osterman; Rob Mazzarese; Todd E. Kerner

doi:10.1117/12.304343

2 April 1998 Electrical impedance imaging for tissue monitoring and assessment during thermal therapy

Keith D. Paulsen, Alex Hartov, Kendra Sunshine Osterman, Rob Mazzarese, Todd E. Kerner

Proceedings Volume 3249, Surgical Applications of Energy; (1998) https://doi.org/10.1117/12.304343
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Electrical properties of tissues in the 10 KHz to 10 MHz range are known to be temperature sensitive making the monitoring and assessment of thermal insult delivered for therapeutic purposes possible through imaging schemes which spatially resolve these changes. We have been developing electrical impedance imaging technology from both the hardware data acquisition and software image reconstruction perspectives in order to realize the capability of spectroscopically examining the electrical property response of tissues undergoing hyperthermia therapy. Results from simulations, in vitro phantom experiments and in vivo studies including in human patients are presented. Specifically, a new prototype multi-frequency data acquisition system which is functional to 1 MHz in both voltage and current modes is described. In addition, recent advances in image reconstruction methods which include the enhancement techniques of total variation minimization, dual meshing and spatial filtering are discussed. It is also clear that the electrical impedance spectrum of tissue has the potential to monitor other types of treatment-induced injury. Preliminary in vivo electrical impedance measurements in a rat leg model suggest that the tissue damage from radiation therapy can be tracked with this technique. Both dose and time-dependent responses have been observed in the electrical impedance data when compared to measurements recorded in an untreated control. Correlations with histological examination have also been performed and indicate that electrical impedance spectroscopy may provide unique information regarding tissue functional status and cellular morphology. Representative results from these studies are reported.

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Keith D. Paulsen, Alex Hartov, Kendra Sunshine Osterman, Rob Mazzarese, and Todd E. Kerner "Electrical impedance imaging for tissue monitoring and assessment during thermal therapy", Proc. SPIE 3249, Surgical Applications of Energy, (2 April 1998); https://doi.org/10.1117/12.304343

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KEYWORDS

Tissues

Analog electronics

Electrodes

Data acquisition

Image restoration

Injuries

Digital electronics

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