Prostate thermal therapy with interstitial and transurethral ultrasound applicators: a feasibility study

Chris J. Diederich; William H. Nau; Dana L. Deardorff; Ismail S. Khalil-Bustany; Everette C. Burdette; Paul R. Stauffer; Max C. Wu

doi:10.1117/12.304342

2 April 1998 Prostate thermal therapy with interstitial and transurethral ultrasound applicators: a feasibility study

Chris J. Diederich, William H. Nau, Dana L. Deardorff, Ismail S. Khalil-Bustany, Everette C. Burdette, Paul R. Stauffer, Max C. Wu

Author Affiliations +

Proceedings Volume 3249, Surgical Applications of Energy; (1998) https://doi.org/10.1117/12.304342
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

The purpose of this study was to determine the feasibility of using a transurethral ultrasound applicator in combination with implantable ultrasound applicators for inducing thermal coagulation and necrosis of localized cancer lesions or BPH within the prostate gland. The concept being evaluated is the potential to treat target zones in the anterior and lateral portions of the prostate with the transurethral applicator, while simultaneously treating regions of extracapsular extension and zones in the posterior prostate with the directive implantable applicators in combination with a rectal cooling bolus. Biothermal computer simulations, acoustic characterizations, and in vivo thermal dosimetry experiments were used to evaluate the performance of each applicator type and combinations thereof. The preliminary results of this investigation demonstrate that implantable ultrasound applicators, in combination with a transurethral ultrasound applicator, have the potential to provide thermal coagulation and necrosis of small or large regions within the prostate gland, while sparing thermally sensitive rectal tissue.

Citation Download Citation

Chris J. Diederich, William H. Nau, Dana L. Deardorff, Ismail S. Khalil-Bustany, Everette C. Burdette, Paul R. Stauffer, and Max C. Wu "Prostate thermal therapy with interstitial and transurethral ultrasound applicators: a feasibility study", Proc. SPIE 3249, Surgical Applications of Energy, (2 April 1998); https://doi.org/10.1117/12.304342

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