Evaluation of incoherent light mixing effects on the quality of DLS data in a fiber optic setup for biological fluids and tissues

Rafat R. Ansari; Gary R. Gray; Jerri Ling; Jason Knight

doi:10.1117/12.311879

19 June 1998 Evaluation of incoherent light mixing effects on the quality of DLS data in a fiber optic setup for biological fluids and tissues

Rafat R. Ansari, Gary R. Gray, Jerri Ling, Jason Knight

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Proceedings Volume 3252, Optical Diagnostics of Biological Fluids III; (1998) https://doi.org/10.1117/12.311879
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Dynamic light scattering (DLS) measurements are mostly performed in dark rooms. Flare and external lights must be avoided in the design of such systems. Recent advancements in optoelectronic devices and fiber optic technology has opened up applications of DLS in areas where a few years ago, their use could not be imagined. We present a compact and flexible fiber optic DLS system with optical viewing (imaging) capability to monitor biological fluids and tissues in-vivo or in-situ in real time. The optical port requires white light illumination for sample viewing or video linking. An evaluation of the effects of mixing white illumination photons with launched coherent (red) photons on the DLS data will be made. Effects such as spatial coherence factors and the reliability in determining accurate particle size from such measurements are evaluated.

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Rafat R. Ansari, Gary R. Gray, Jerri Ling, and Jason Knight "Evaluation of incoherent light mixing effects on the quality of DLS data in a fiber optic setup for biological fluids and tissues", Proc. SPIE 3252, Optical Diagnostics of Biological Fluids III, (19 June 1998); https://doi.org/10.1117/12.311879

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KEYWORDS

Particles

Photons

Fiber optics

Light scattering

Scattering

Tissues

Dispersion

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