Morphological studies of metastatic mammary rat tumors after laser immunotherapy treatment

Robert E. Nordquist; John A. Nordquist; James C. Agee; Chad M. Blomquist; Wei R. Chen

doi:10.1117/12.308195

13 May 1998 Morphological studies of metastatic mammary rat tumors after laser immunotherapy treatment

Robert E. Nordquist, John A. Nordquist, James C. Agee, Chad M. Blomquist, Wei R. Chen

Proceedings Volume 3254, Laser-Tissue Interaction IX; (1998) https://doi.org/10.1117/12.308195
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Laser immunotherapy, using a combination of 805 nm diode laser, photosensitizer indocyanine green and immunoadjuvant glycated chitosan, has shown an induced anti-tumor immune response in treatment of metastatic rat tumors. In additional to an apparent systemic, long-term humoral immunological reaction, there could also be laser induced local cellular immune responses. A morphological study was performed to study the immune cells and their infiltration to tumor tissue after this laser immunotherapy treatment. Tumor-bearing rats were terminated at designated times after the treatment; both the tumor and the surrounding normal tissue were collected. The tissue samples were observed under electron microscope. The number and types of infiltrating cells at the tumor site were studied after treatment to determine the contribution of these cells in the elimination of tumors. The tumor cell structural changes resulted from laser-tissue photothermal interaction was investigated. The morphology of tumor development and activities of immune cells including both lymphocytes and plasma cells could shed light on the mode of action of laser treatment of tumors.

Citation Download Citation

Robert E. Nordquist, John A. Nordquist, James C. Agee, Chad M. Blomquist, and Wei R. Chen "Morphological studies of metastatic mammary rat tumors after laser immunotherapy treatment", Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); https://doi.org/10.1117/12.308195

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