In-vivo tissue response to the free-electron laser

Cynthia A. Toth M.D.; Eric Kelvin Chiu; Katrina P. Winter; Michelle L. Norton McCall; Sarah F. Bailey; Susanne Hauger

doi:10.1117/12.350613

18 June 1999 In-vivo tissue response to the free-electron laser

Cynthia A. Toth M.D., Eric Kelvin Chiu, Katrina P. Winter, Michelle L. Norton McCall, Sarah F. Bailey, Susanne Hauger

Proceedings Volume 3591, Ophthalmic Technologies IX; (1999) https://doi.org/10.1117/12.350613
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Purpose: We analyzed the effect of energy and rate of cutting on the in vivo ocular response to 2.94 μm wavelength Free Electron Laser incision of the cornea. We were interested in the difference between our clinical observations of the initial laser lesion and the ocular response using the biomicroscope versus optical coherence tomographs. We were also interested in the difference between these clinical in vivo data and our findings from light micrographs of fixed tissue. Methods: Corneas were incised with FEL at 2.94 μm wavelength and either 2.5 or 3.5 mJ/1.4 μsec. the rate of movement of the laser beam across tissue ranged from 0.2 mm/sec to 1.2 mm/sec. Eyes were examined for two hours postoperatively using optical coherence tomography (OCT) and compared to the clinical slit lamp examination and to light microscopic examination of fixed tissue sections. Results: OCT revealed a dramatic fibrin response directly correlated to the slow sweep of the FEL beam across the tissue (longer duration of tissue exposure to the laser beam). The OCt was better than examination at the slit lamp at demonstrating sites of fibrin attachments.

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Cynthia A. Toth M.D., Eric Kelvin Chiu, Katrina P. Winter, Michelle L. Norton McCall, Sarah F. Bailey, and Susanne Hauger "In-vivo tissue response to the free-electron laser", Proc. SPIE 3591, Ophthalmic Technologies IX, (18 June 1999); https://doi.org/10.1117/12.350613

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KEYWORDS

Optical coherence tomography

Cornea

Free electron lasers

Laser tissue interaction

Photomicroscopy

Tissues

Tissue optics

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