Examples of adjuvant treatment enhancing the antitumor effect of photodynamic therapy

Mladen Korbelik; Ivana Cecic; Jinghai Sun; David J. Chaplin

doi:10.1117/12.351507

6 July 1999 Examples of adjuvant treatment enhancing the antitumor effect of photodynamic therapy

Mladen Korbelik, Ivana Cecic, Jinghai Sun, David J. Chaplin

Proceedings Volume 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII; (1999) https://doi.org/10.1117/12.351507
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Strategies for improving the clinical efficacy of photodynamic therapy (PDT) in treatment of solid cancers include applications of different types of adjuvant treatments in addition to this modality that may result in superior therapeutic outcome. Examples of such an approach investigated using mouse tumor models are presented in this report. It is shown that the cures of PDT treated subcutaneous tumors can be substantially improved by adjuvant therapy with: metoclopramide (enhancement of cancer cell apoptosis), combretastatin A-4 (selective destruction of tumor neovasculature), Roussin's Black Salt (light activated tumor localized release of nitric oxide), or dendritic cell-based adoptive immunotherapy (immune rejection of treated tumor).

Citation Download Citation

Mladen Korbelik, Ivana Cecic, Jinghai Sun, and David J. Chaplin "Examples of adjuvant treatment enhancing the antitumor effect of photodynamic therapy", Proc. SPIE 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII, (6 July 1999); https://doi.org/10.1117/12.351507

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