Time-dependent speckle contrast measurements for blood microcirculation monitoring

Dmitry A. Zimnyakov; Alexey B. Mishin; Andrey A. Bednov; Cecil Cheung; Valery V. Tuchin; Arjun G. Yodh

doi:10.1117/12.348369

17 May 1999 Time-dependent speckle contrast measurements for blood microcirculation monitoring

Dmitry A. Zimnyakov, Alexey B. Mishin, Andrey A. Bednov, Cecil Cheung, Valery V. Tuchin, Arjun G. Yodh

Proceedings Volume 3599, Optical Diagnostics of Biological Fluids IV; (1999) https://doi.org/10.1117/12.348369
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Features of the speckle patterns formation due to the laser light propagation in multiple scattering systems which influence on the accuracy of measurement of the scattering system dynamic parameters by means of statistical analysis of the time-averaged spatial speckle intensity fluctuations have been studied experimentally. Two different experimental techniques have been used: photon correlation spectroscopy and contrast analysis for time-averaged speckle patterns similar to LASCA method. Results of in-vivo experiments as well as experiments with model scattering media (water solution of Intralipid) are presented. Recommendations about the choose of appropriate data processing algorithms as well as about calibration technique for time-averaged speckle technique are discussed.

Citation Download Citation

Dmitry A. Zimnyakov, Alexey B. Mishin, Andrey A. Bednov, Cecil Cheung, Valery V. Tuchin, and Arjun G. Yodh "Time-dependent speckle contrast measurements for blood microcirculation monitoring", Proc. SPIE 3599, Optical Diagnostics of Biological Fluids IV, (17 May 1999); https://doi.org/10.1117/12.348369

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