Drug penetration into and permeation through human skin assessed by Raman spectroscopy

Adrian C. Williams; Elizabeth A. Carter; Howell G.M. Edwards; Brian W. Barry

doi:10.1117/12.345385

9 April 1999 Drug penetration into and permeation through human skin assessed by Raman spectroscopy

Adrian C. Williams, Elizabeth A. Carter, Howell G.M. Edwards, Brian W. Barry

Proceedings Volume 3608, Biomedical Applications of Raman Spectroscopy; (1999) https://doi.org/10.1117/12.345385
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

FT-Raman spectroscopy has been used as a tool for investigating permeation into and diffusion through human skin membranes. Thermal studies showed that the lipid component of stratum corneum, the outermost layer of skin and the main barrier to diffusion of most drugs, is disrupted as the lipids melt. This measure for disruption provides a positive control against which penetration enhancer effects on the lipids can be judged. 1,8-Cineole, a model enhancer unexpectedly increases order in the lipid domains, probably as a result of phase separation within the tissue although permeation defects where the enhancer bounds the skin lipids may allow improved drug flux. Permeation through skin membranes was successfully followed for simple one component permeants but with more complex mixtures of permeants there were several technical problems, which require further attention. However, the result suggest that the technique may be valuable for examining permeation of complex mixtures through membranes.

Citation Download Citation

Adrian C. Williams, Elizabeth A. Carter, Howell G.M. Edwards, and Brian W. Barry "Drug penetration into and permeation through human skin assessed by Raman spectroscopy", Proc. SPIE 3608, Biomedical Applications of Raman Spectroscopy, (9 April 1999); https://doi.org/10.1117/12.345385

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