Influence of osmotically active chemical agents on the transport of light in scleral tissue

Alexey N. Bashkatov; Elina A. Genina; Vyacheslav I. Kochubey; Valery V. Tuchin; Yurii P. Sinichkin

doi:10.1117/12.341424

4 March 1999 Influence of osmotically active chemical agents on the transport of light in scleral tissue

Alexey N. Bashkatov, Elina A. Genina, Vyacheslav I. Kochubey, Valery V. Tuchin, Yurii P. Sinichkin

Proceedings Volume 3726, Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science; (1999) https://doi.org/10.1117/12.341424
Event: Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science, 1998, Saratov, Russian Federation

Abstract

Experimental study and computer simulation were used to analyze tissue optics during a process of optical clearing due to refractive index matching. Tissue samples of the human and bovine sclera and the collagen sponge as a phantom were investigated. Osmotically active solutions, such as verografin and propylene glycol, were used as chemicals. A characteristic time response of human scleral optical clearing in the range 1 to 20 min was determined. The matter diffusion coefficient for the scleral samples to impregnated by verografin solution were experimentally estimated; the average value is 1.27 (DOT) 10^-5 +/- 3.77 (DOT) 10^-6 cm²/sec. The results are general and can be used to describe many other fibrous tissues.

Citation Download Citation

Alexey N. Bashkatov, Elina A. Genina, Vyacheslav I. Kochubey, Valery V. Tuchin, and Yurii P. Sinichkin "Influence of osmotically active chemical agents on the transport of light in scleral tissue", Proc. SPIE 3726, Saratov Fall Meeting '98: Light Scattering Technologies for Mechanics, Biomedicine, and Material Science, (4 March 1999); https://doi.org/10.1117/12.341424

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