Single-breath NO detection with tunable diode lasers for pulmonary disease diagnosis

Eugene V. Stepanov; Pavel V. Zyrianov; Valerii A. Miliaev

doi:10.1117/12.353112

14 July 1999 Single-breath NO detection with tunable diode lasers for pulmonary disease diagnosis

Eugene V. Stepanov, Pavel V. Zyrianov, Valerii A. Miliaev

Proceedings Volume 3829, ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology; (1999) https://doi.org/10.1117/12.353112
Event: Selected Papers from Seventh International Conference on Advanced Laser Technologies (ALT'98): Laser Methods in Medicine and Biology, 1998, Tallin, Estonia

Abstract

An analyzer aimed for single-breath detection of exhaled endogenous NO is described. It is based on lead-salt MBE tunable diode lasers (TDL) operating at 5.4 micrometers spectral region. Specially designed high sensitive and fast acquisition system used in combination with the Herriott multipass gas cell allows 1 ppb concentration sensitivity to exhaled NO with about 0.5 s temporal resolution. Careful selection of the used analytical spectral region ensures high NO detection selectivity in the conduction if elevated water vapor and carbon dioxide content in exhaled air. Due to the TDL high spectral resolution the analyzer is also insensitive to the other numerous endogenous substances that could be present in exhaled air. The TDL NO analyzer was tested in measuring endogenous NO content in exhalation of patients suffering from different pulmonary diseases as well as of healthy control subjects. Some single-breath NO trace specific in asthma and COPD was observed allowing differentiation of these diseases with the exhalation NO test.

Citation Download Citation

Eugene V. Stepanov, Pavel V. Zyrianov, and Valerii A. Miliaev "Single-breath NO detection with tunable diode lasers for pulmonary disease diagnosis", Proc. SPIE 3829, ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology, (14 July 1999); https://doi.org/10.1117/12.353112

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