Optimization of solid-phase syntheses via online spectroscopic monitoring

Dwight S. Walker; Joanne M. Anderson; Frank J. Tarczynski

doi:10.1117/12.372932

9 December 1999 Optimization of solid-phase syntheses via online spectroscopic monitoring

Dwight S. Walker, Joanne M. Anderson, Frank J. Tarczynski

Proceedings Volume 3859, Optical Online Industrial Process Monitoring; (1999) https://doi.org/10.1117/12.372932
Event: Photonics East '99, 1999, Boston, MA, United States

Abstract

Conventional solution-phase chemical synthesis involves a number of discrete synthetic steps from which intermediates and products are isolated for characterization at the completion of each step. In solid-phase synthesis, intermediates are linked to a solid support and are not removed until the product is isolated at synthesis completion. This approach facilitates the removal of unwanted by-products and maximizes yield. Solid-phase synthetic procedures typically suffer form a number of drawbacks including the use of large excesses of reagents to drive reactions to completion, long reaction times, and large volumes of solvent washes required to remove unreacted reagents between steps. This work describes the use of spectroscopic techniques to optimize solid phase synthesis by making measurements in both the solid and liquid phases. These measurements can lead to faster processing times, reduced chemical waste, and a reduction in the amount of reagents used. 4

Citation Download Citation

Dwight S. Walker, Joanne M. Anderson, and Frank J. Tarczynski "Optimization of solid-phase syntheses via online spectroscopic monitoring", Proc. SPIE 3859, Optical Online Industrial Process Monitoring, (9 December 1999); https://doi.org/10.1117/12.372932

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available