FCLA-assisted photodynamic diagnosis

Yonghong He; Yonghong Tang; Shici Tan; Da Xing

doi:10.1117/12.364345

17 September 1999 FCLA-assisted photodynamic diagnosis

Yonghong He, Yonghong Tang, Shici Tan, Da Xing

Proceedings Volume 3863, 1999 International Conference on Biomedical Optics; (1999) https://doi.org/10.1117/12.364345
Event: International Symposium on Biomedical Optics, 1999, Wuhan, China

Abstract

Conventional Photo-Dynamic Diagnosis has several serious limitations, such as autofluorescence disturbance, poor penetration ability of the exciting laser etc. All these problems are because the exciting laser wavelength at the main absorption peak of the photosensitizer (e.g. HpD) is too short. But to our knowledge, long wavelength He-Ne laser can sensitize appropriate sensitizer to produce singlet oxygen (¹O₂) without autofluorescence of the normal tissues. The ¹O₂ can react with FCLA (5-Fluoresceinyl Cypridina Luminescent Analog) to emit chemiluminescence at the peak wavelength 532 nm, thus we can use a high sensitivity detector to image the emission from FCLA to make a localization of the cancer. This is a novel idea proposed by our group, and its feasibility was proved by our experiments.

Citation Download Citation

Yonghong He, Yonghong Tang, Shici Tan, and Da Xing "FCLA-assisted photodynamic diagnosis", Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); https://doi.org/10.1117/12.364345

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