Photomodification of sensitizers commonly used in photosensitized tumor therapy

Ricardas Rotomskis; Saulius Bagdonas; Petras Juzenas; Dimitry Y. Frolov; Giedre Streckyte

doi:10.1117/12.364344

17 September 1999 Photomodification of sensitizers commonly used in photosensitized tumor therapy

Ricardas Rotomskis, Saulius Bagdonas, Petras Juzenas, Dimitry Y. Frolov, Giedre Streckyte

Proceedings Volume 3863, 1999 International Conference on Biomedical Optics; (1999) https://doi.org/10.1117/12.364344
Event: International Symposium on Biomedical Optics, 1999, Wuhan, China

Abstract

Photostability studies of porphyrin-type sensitizers performed in aqueous solutions, model systems (sensitizers bound to human serum albumin or in a suspension of released erythrocyte ghosts) and in tumor tissue reveal that similar photomodification takes place in all investigated environments: photobleaching during exposure to light is followed by the formation of red-absorbing photoproducts. Photoproducts are not formed in the solutions of the less photostable sensitizer chlorin e₆ and the most photostable sensitizer aluminum phthalocyanine tetrasulphonate. Interaction with photooxidizable biomolecules increases the photobleaching rate of porphyrin-type sensitizers. This should be taken into account in the estimation of optimal photodynamic doses. The modified formula including photodestruction of sensitizer and formation of photoproduct is suggested.

Citation Download Citation

Ricardas Rotomskis, Saulius Bagdonas, Petras Juzenas, Dimitry Y. Frolov, and Giedre Streckyte "Photomodification of sensitizers commonly used in photosensitized tumor therapy", Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); https://doi.org/10.1117/12.364344

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