Mathematical model of epidermal melanin content control for PUVA therapy seances

Mikhail M. Stolnitz; Anna Yu. Peshkova

doi:10.1117/12.381524

6 April 2000 Mathematical model of epidermal melanin content control for PUVA therapy seances

Mikhail M. Stolnitz, Anna Yu. Peshkova

Proceedings Volume 4001, Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine; (2000) https://doi.org/10.1117/12.381524
Event: Saratov Fall Meeting '99, 1999, Saratov, Russian Federation

Abstract

'Me1anin screen" effect, i.e. the increase of epiderinal absorption due to UV-induced melanogenesis leads to decrease of effective doses of UVA-radiation at subsequent photochemotherapy sessions. In the work the mathematical model of melanogenesis. induced by sequence of UVA-radiation "pulses" ,is developed. Processes on cellular, subcellular and molecular levels are described. The structure of equations allows to split the problem and to consider differential equations system at given intensity, to calculate a melanin distribution and absorption coefficient, to define a new value of intensity etc. The melanin content in basal and upper layers is defined. The time and dose dependencies of epidermal absorption coefficient are determined. Thus using the presented model it is possible to inspect a modification of modes during PUVAtherapy.

Citation Download Citation

Mikhail M. Stolnitz and Anna Yu. Peshkova "Mathematical model of epidermal melanin content control for PUVA therapy seances", Proc. SPIE 4001, Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine, (6 April 2000); https://doi.org/10.1117/12.381524

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