Sensitized action of low-level laser radiation mechanism

Tatyana V. Chichuk; Eugeny Ph. Stranadko; G. N. Lubchenko; E. V. Podgornaya; E. E. Pozdnyakova; Gennady I. Klebanov

doi:10.1117/12.375253

30 December 1999 Sensitized action of low-level laser radiation mechanism

Tatyana V. Chichuk, Eugeny Ph. Stranadko, G. N. Lubchenko, E. V. Podgornaya, E. E. Pozdnyakova, Gennady I. Klebanov

Proceedings Volume 4059, Laser Use in Oncology II; (1999) https://doi.org/10.1117/12.375253
Event: Selected Papers on Laser Use in Oncology II, 1999, none, Armenia

Abstract

The goal of this work is to study the laser-induced photosensitized oxidation of lipids of the artificial (lyposomes) and cell's (erythrocytes, leukocytes) membranes and human blood lipoproteins. As a exogenous photosensitizers we are used hematoporphyrin derivatives (HPD) and sulfonated phthalocyanine aluminum (Pc). Irradiation was performed by helium-neon laser (632.8 nm). It was found out the increasing of the products of lipid oxidation in the suspensions of a lyposomes, human blood apo-(beta) -lipoproteins, erythrocytes and leucocytes. Accumulation of the lipid oxidation products depend on as irradiation dose as HPD or Pc concentrations. Interaction of photosensitizers with the lyposomes, lipoproteins and erythrocytes was investigated.

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Tatyana V. Chichuk, Eugeny Ph. Stranadko, G. N. Lubchenko, E. V. Podgornaya, E. E. Pozdnyakova, and Gennady I. Klebanov "Sensitized action of low-level laser radiation mechanism", Proc. SPIE 4059, Laser Use in Oncology II, (30 December 1999); https://doi.org/10.1117/12.375253

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