Photobleaching of endogenous fluorochroms in tissues in vivo during laser irradiation

Alexander A. Stratonnikov; Vladimir S. Polikarpov; Victor B. Loschenov

doi:10.1117/12.431555

4 May 2001 Photobleaching of endogenous fluorochroms in tissues in vivo during laser irradiation

Alexander A. Stratonnikov, Vladimir S. Polikarpov, Victor B. Loschenov

Proceedings Volume 4241, Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II; (2001) https://doi.org/10.1117/12.431555
Event: Saratov Fall Meeting 2000, 2001, Saratov, Russian Federation

Abstract

The photobleaching phenomenon has been previously first of all widely studied for exogenous photosensitizers applied in photodynamic therapy (PDT). The present paper deals with detailed investigation of photobleaching of endogenous fluorochroms in tissues in vivo during its laser irradiation at 532, 633 and 670 nm at different powers. The fluorescence decay curves during skin irradiation in vivo at these wavelengths have been obtained and analyzed. The similarity in bleaching behavior of endogenous fluorochroms and exogenous photosensitizers used in PDT gave us the reasons to imply the possible connection between native fluorochroms and low intensity laser therapy effects. The results obtained may be applied for tissue diagnostics and therapy control.

Citation Download Citation

Alexander A. Stratonnikov, Vladimir S. Polikarpov, and Victor B. Loschenov "Photobleaching of endogenous fluorochroms in tissues in vivo during laser irradiation", Proc. SPIE 4241, Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II, (4 May 2001); https://doi.org/10.1117/12.431555

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available