ED50 determination of corneal lesions produced by 1318-nm laser radiation pulses

Bryan K. Ketzenberger; Thomas E. Johnson; Steven P. Wild; Kenneth B. Pletcher; William P. Roach

doi:10.1117/12.427844

21 May 2001 ED₅₀ determination of corneal lesions produced by 1318-nm laser radiation pulses

Bryan K. Ketzenberger, Thomas E. Johnson, Steven P. Wild, Kenneth B. Pletcher, William P. Roach

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427844
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

High-energy use of 1318 nm laser systems is becoming more prevalent in military and industrial settings. Threshold, ED₅₀, exposure data and mechanism of laser-tissue interaction need to be determined for this wavelength using appropriate animal models that allow for extrapolation to control human exposures. Threshold, ED₅₀, exposure data at 1318 nm for retinal and corneal injury have previously been undertaken and reported for rhesus monkeys. Using comparable methods, we examine exposure data at 1318 nm to determine the ED₅₀ and laser-tissue interaction in the rabbit model to evaluate cornea. We present preliminary data for the ED₅₀ threshold on the cornea from exposure to 1318 nm single laser pulses. Delivery of laser energy is accomplished using an Nd:YAG system producing 1318 nm light in the 0.5 millisecond time exposure regime and in the range of 0 to 500 mJ. Results from this work will aid in the establishment of safety standards for near infrared laser systems.

Citation Download Citation

Bryan K. Ketzenberger, Thomas E. Johnson, Steven P. Wild, Kenneth B. Pletcher, and William P. Roach "ED₅₀ determination of corneal lesions produced by 1318-nm laser radiation pulses", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427844

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