Imaging the internal structure of the guinea pig cochlea using optical coherence tomography at 1310 nm

Mark K. Yamaguchi; Johannes F. de Boer; Boris Hyle Park; Nader Nassif; Yonghua Zhao; Zhongping Chen; Brian Jet-Fei Wong M.D.

doi:10.1117/12.427820

21 May 2001 Imaging the internal structure of the guinea pig cochlea using optical coherence tomography at 1310 nm

Mark K. Yamaguchi, Johannes F. de Boer, Boris Hyle Park, Nader Nassif, Yonghua Zhao, Zhongping Chen, Brian Jet-Fei Wong M.D.

Author Affiliations +

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427820
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Optical coherence tomography (OCT) was used to obtain cross sectional images of the internal structure of the cochlea in guinea pigs following sacrifice. The 1310 nm source (bandwidth (lambda) equals75 nm) allowed a penetration depth of approximately 1.5 mm. Cross-sectional images (1.87 x 2.00 mm, 10 x 10 micrometers /pixel) were acquired at a frame rate of 1 Hz. Access to the middle ear space was obtained by removing the mastoid bulla. Imaging was performed in situ and also in ex vivo temporal bones. The scala vestibuli, scala media, scala tympani, modiolus and all four and a half turns of the cochlea were identified. These images demonstrate the potential value of OCT for use in determining the internal structures of the cochlea with near-microscopic resolution and at near-real time frame rates.

Citation Download Citation

Mark K. Yamaguchi, Johannes F. de Boer, Boris Hyle Park, Nader Nassif, Yonghua Zhao, Zhongping Chen, and Brian Jet-Fei Wong M.D. "Imaging the internal structure of the guinea pig cochlea using optical coherence tomography at 1310 nm", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427820

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available