Immersion technique as a tool for in-depth OCT imaging through human blood and body's interior tissues

Xiangqun Xu; Valery V. Tuchin; Ruikang K. Wang

doi:10.1117/12.427877

23 May 2001 Immersion technique as a tool for in-depth OCT imaging through human blood and body's interior tissues

Xiangqun Xu, Valery V. Tuchin, Ruikang K. Wang

Proceedings Volume 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V; (2001) https://doi.org/10.1117/12.427877
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The concept of refractive index matching used for the enhancement of optical penetration depth of the whole blood is discussed on the basis of in vitro studies using optical coherence tomography technique. It was found that blood optical clearing is defined not only by refractive index matching effect, but also by changes of RBC size and their aggregation ability when chemicals are added. Chemical agents studied include glycerol, propylene glycol, trazograph, and dextrans. For the hyperosmotic agents, the application of 6.5% glycerol into twice diluted blood reduces the total attenuation coefficient from 4.2/mm to 2.0/mm, and correspondingly increases the optical penetration at 820 nm up to 117%. Similar effects of increase in transmittance and decrease in light scattering are also demonstrated by various molecular detrans with the light penetration enhancement within a range between 52.1% and 150.5%. We also demonstrate that the use of biocompatible agents could enhance in-depth imaging of the human esophagus and stomach tissues.

Citation Download Citation

Xiangqun Xu, Valery V. Tuchin, and Ruikang K. Wang "Immersion technique as a tool for in-depth OCT imaging through human blood and body's interior tissues", Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, (23 May 2001); https://doi.org/10.1117/12.427877

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