2D line-scan photoacoustic imaging of absorbers in a scattering tissue phantom

Paul C. Beard; Timothy N. Mills

doi:10.1117/12.429319

15 June 2001 2D line-scan photoacoustic imaging of absorbers in a scattering tissue phantom

Paul C. Beard, Timothy N. Mills

Proceedings Volume 4256, Biomedical Optoacoustics II; (2001) https://doi.org/10.1117/12.429319
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

A photoacoustic imaging system has been evaluated by mapping the temporal distribution of photoacoustic signals generated in a tissue phantom. The phantom comprised an Intralipid scattering solution (μ_s'=1mm^-1 and μ_a=0.01mm^-1) containing two regions of enhanced absorption; a 1.5mm thick layer (μ_a=1mm^-1) and a 75μm layer (μ_a=40mm^-1). These were located 1cm beneath the surface of the Intralipid which was irradiated with 7ns Q switched laser pulses of fluence 0.05 J/cm². A Fabry Perot polymer film ultrasound sensing interferometer was used for the detection of the photoacoustic signals. A 1D ultrasound array was simulated by illuminating the sensing interferometer with a large diameter laser beam and line scanning a photodiode across the reflected output beam. The detection sensitivity of the system was 3kPA over a 25MHz measurement bandwidth, the 3dB acoustic bandwidth was 17.5MHz, the sensitive azimuthal 'array' aperture and element size were 12mm and 0.8mm respectively. Greyscale images of the time-resolved photoacoustic signals enabled both absorbers to be clearly identified with an axial spatial resolution of less than 100micrometers . It is envisaged that this approach could form the basis of a practical photoacoustic tissue imaging system.

Citation Download Citation

Paul C. Beard and Timothy N. Mills "2D line-scan photoacoustic imaging of absorbers in a scattering tissue phantom", Proc. SPIE 4256, Biomedical Optoacoustics II, (15 June 2001); https://doi.org/10.1117/12.429319

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