Multiple-reader studies, digital mammography, computer-aided diagnosis, and the Holy Grail of imaging physics: I

Robert F. Wagner; Sergey V. Beiden; Gregory Campbell

doi:10.1117/12.430881

28 June 2001 Multiple-reader studies, digital mammography, computer-aided diagnosis, and the Holy Grail of imaging physics: I

Robert F. Wagner, Sergey V. Beiden, Gregory Campbell

Author Affiliations +

Proceedings Volume 4320, Medical Imaging 2001: Physics of Medical Imaging; (2001) https://doi.org/10.1117/12.430881
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

There are multiple sources of variability in clinical studies of imaging systems. The variation of the reader `mindset' establishes the need for ROC analysis to control for that fundamental variable. The demonstration of the range of reader skills in mammography shows the need for a multivariate approach to ROC analysis. The multiple-reader, multiple-case (MRMC) ROC experimental paradigm addresses this need and several practical solutions to the problem of analysis of MRMC data have been developed. We review the application of these methods to an important clinical comparison of digital and conventional mammography.

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Robert F. Wagner, Sergey V. Beiden, and Gregory Campbell "Multiple-reader studies, digital mammography, computer-aided diagnosis, and the Holy Grail of imaging physics: I", Proc. SPIE 4320, Medical Imaging 2001: Physics of Medical Imaging, (28 June 2001); https://doi.org/10.1117/12.430881

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