Alexander A. Karabutov,1 Valeri A. Andreev,1 Brent A. Bell,1 R. Declan Fleming,1 Zoran Gatalica,1 Massoud Motamedi,1 Elena V. Savateeva,1 Harbans Singh,1 Sergey V. Solomatin,1 Sharon L. Thomsen M.D.,2 P. Mark Henrichs,3 Alexander A. Oraevsky1
1Univ. of Texas Medical Branch at Galveston (United States) 2M.D. Anderson Cancer Ctr. (United States) 3LaserSonix Technologies Inc. (United States)
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Optoacoustic tomography combines advantages of pronounced optical contrast between different tissues and high resolution of ultrawide-band ultrasound imaging. Laser pulses may be effectively used to produce acoustic sources in tissue with enhanced optical absorption. Ultrasonic waves can propagate in biological tissue with minimal distortion and deliver diagnostic information to the surface of tissue, where they may be detected with temporal resolution by piezoelectric transducers. Current status of the optoacoustic tomography applied in early detection of cancerous lesions in the breast (utilizing forward mode) and in oral cavity (utilizing backward mode) is reviewed.
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Alexander A. Karabutov, Valeri A. Andreev, Brent A. Bell, R. Declan Fleming, Zoran Gatalica, Massoud Motamedi, Elena V. Savateeva, Harbans Singh, Sergey V. Solomatin, Sharon L. Thomsen M.D., P. Mark Henrichs, Alexander A. Oraevsky, "Optoacoustic images of early cancer in forward and backward modes," Proc. SPIE 4434, Hybrid and Novel Imaging and New Optical Instrumentation for Biomedical Applications, (24 October 2001); https://doi.org/10.1117/12.446687