Function of immunoadjuvants in laser immunotherapy for treatment of metastatic breast tumors in rats

Wei R. Chen; Hong Liu; Roman F. Wolf D.V.M.; Michael D. Lucroy D.V.M.; Robert E. Nordquist

doi:10.1117/12.472522

27 June 2002 Function of immunoadjuvants in laser immunotherapy for treatment of metastatic breast tumors in rats

Wei R. Chen, Hong Liu, Roman F. Wolf D.V.M., Michael D. Lucroy D.V.M., Robert E. Nordquist

Proceedings Volume 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical; (2002) https://doi.org/10.1117/12.472522
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Tumor cell destruction usually induces host immune responses, such as local inflammation and increased activities of macrophages and neutrophils. Use of immunoadjuvant can usually enhance such immune activities. Laser immunotherapy is designed to use the combination of laser photothermal and immunological interactions to induce long-term antitumor immunity with the help of immunoadjuvant. It uses a selective hyperthermia for acute tumor destruction through an intratumor administration of indocyanine green and a noninvasive irradiation by an 805-nm laser. The concurrent in situ administration of immunoadjuvant helped achieve the desired effect: tumor eradication and antitumor immunity. The current study further explores the function of immunoadjuvants in laser immunotherapy by testing four different adjuvants: glycated chitosan, complete Freund's adjuvant, incomplete Freund's adjuvant, and c-parvum. Each adjuvant provided long-term tumor cure in the treatment of a metastatic mammary tumor model in rats. However, glycated chitosan and complete Freund's adjuvant were most effective with 25% and 18% long- term cure rates, respectively. Different concentrations of glycated chitosan were also used in treatment of rats bearing metastatic breast tumors.

Citation Download Citation

Wei R. Chen, Hong Liu, Roman F. Wolf D.V.M., Michael D. Lucroy D.V.M., and Robert E. Nordquist "Function of immunoadjuvants in laser immunotherapy for treatment of metastatic breast tumors in rats", Proc. SPIE 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical, (27 June 2002); https://doi.org/10.1117/12.472522

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