Selective photothermal interaction using near-infrared laser and laser-absorbing dye in gel phantom and chicken breast tissue

Thomas M. Cowan; Guangyu Liu; Sarah Simmons; Jeremy Real; Michael D. Lucroy D.V.M.; Kenneth Eugene Bartels D.V.M.; Robert E. Nordquist; Wei R. Chen

doi:10.1117/12.472528

27 June 2002 Selective photothermal interaction using near-infrared laser and laser-absorbing dye in gel phantom and chicken breast tissue

Thomas M. Cowan, Guangyu Liu, Sarah Simmons, Jeremy Real, Michael D. Lucroy D.V.M., Kenneth Eugene Bartels D.V.M., Robert E. Nordquist, Wei R. Chen

Author Affiliations +

Proceedings Volume 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical; (2002) https://doi.org/10.1117/12.472528
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Photothermal interaction of an 805-nm diode laser with an absorptive dye, indocyanine green (ICG), has been shown to be an efficacious therapy for metastatic breast tumors in a rat model when combined with immunoadjuvant. When ICG solution was injected into the target tissue, selective tissue destruction can be achieved. To study the selective photothermal interaction, temperature change in irradiated tissue was achieved. To study the selective photothermal interaction, temperature change in irradiated tissue was studied using chicken breast tissue and phantom composed of gelatin and intralipid. ICG solution was mixed with gel phantom to simulate dye-enhanced target tissue. The target gel was then embedded in chicken breast tissue. The temperature change of irradiated chicken and gel phantom was measured by needle temperature probes at different tissue depths and radii from the center of the laser beam to construct a two-dimensional array of temperature change in a cylindrical coordinate system. It was shown that it is possible to selectively raise the temperature of deep target tissue while not substantially heating nontargeted tissue. A Nd:YAG laser was also used to irradiate the tissue-gel system and the photothermal results were compared with that using the 805-nm laser.

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Thomas M. Cowan, Guangyu Liu, Sarah Simmons, Jeremy Real, Michael D. Lucroy D.V.M., Kenneth Eugene Bartels D.V.M., Robert E. Nordquist, and Wei R. Chen "Selective photothermal interaction using near-infrared laser and laser-absorbing dye in gel phantom and chicken breast tissue", Proc. SPIE 4617, Laser Tissue Interaction XIII: Photochemical, Photothermal, and Photomechanical, (27 June 2002); https://doi.org/10.1117/12.472528

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