Thermal energy effects on articular cartilage: a multidisciplinary evaluation

Lee David Kaplan; John Ernsthausen; Dan S. Ionescu; Rebecca K. Studer; James P. Bradley; Constance R. Chu; Freddie H. Fu M.D.; Daniel L. Farkas

doi:10.1117/12.468358

28 May 2002 Thermal energy effects on articular cartilage: a multidisciplinary evaluation

Lee David Kaplan, John Ernsthausen, Dan S. Ionescu, Rebecca K. Studer, James P. Bradley, Constance R. Chu, Freddie H. Fu M.D., Daniel L. Farkas

Author Affiliations +

Proceedings Volume 4622, Optical Diagnostics of Living Cells V; (2002) https://doi.org/10.1117/12.468358
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Partial thickness articular cartilage lesions are commonly encountered in orthopedic surgery. These lesions do not have the ability to heal by themselves, due to lack of vascular supply. Several types of treatment have addressed this problem, including mechanical debridement and thermal chondroplasty. The goal of these treatments is to provide a smooth cartilage surface and prevent propagation of the lesions. Early thermal chondroplasty was performed using lasers, and yielded very mixed results, including severe damage to the cartilage, due to poor control of the induced thermal effects. This led to the development (including commercial) of probes using radiofrequency to generate the thermal effects desired for chondroplasty. Similar concerns over the quantitative aspects and control ability of the induced thermal effects in these treatments led us to test the whole range of complex issues and parameters involved. Our investigations are designed to simultaneously evaluate clinical conditions, instrument variables for existing radiofrequency probes (pressure, speed, distance, dose) as well as the associated basic science issues such as damage temperature and controllability (down to the subcellular level), damage geometry, and effects of surrounding conditions (medium, temperature, flow, pressure). The overall goals of this work are (1) to establish whether thermal chondroplasty can be used in a safe and efficacious manner, and (2) provide a prescription for multi-variable optimization of the way treatments are delivered, based on quantitative analysis. The methods used form an interdisciplinary set, to include precise mechanical actuation, high accuracy temperature and temperature gradient control and measurement, advanced imaging approaches and mathematical modeling.

Citation Download Citation

Lee David Kaplan, John Ernsthausen, Dan S. Ionescu, Rebecca K. Studer, James P. Bradley, Constance R. Chu, Freddie H. Fu M.D., and Daniel L. Farkas "Thermal energy effects on articular cartilage: a multidisciplinary evaluation", Proc. SPIE 4622, Optical Diagnostics of Living Cells V, (28 May 2002); https://doi.org/10.1117/12.468358

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE