Development of a hydroxyl radical nanoprobe

Matthew King; Raoul Kopelman

doi:10.1117/12.469776

4 June 2002 Development of a hydroxyl radical nanoprobe

Matthew King, Raoul Kopelman

Proceedings Volume 4625, Clinical Diagnostic Systems: Technologies and Instrumentation; (2002) https://doi.org/10.1117/12.469776
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

A hydroxyl radical nanoprobe has been developed by covalently attaching the dye, coumarin-3-carboxylic acid (CCA), to amine-functionalized polyacrylic acid (AFPAA) nanoparticles. These nanoparticles are referred to as PEBBLEs (Probes Encapsulated By Biologically Localized Embedding). This probe has been shown to be highly specific and sensitive. The formation of hydroxyl radical is monitored by an increase in fluorescence over time.

Citation Download Citation

Matthew King and Raoul Kopelman "Development of a hydroxyl radical nanoprobe", Proc. SPIE 4625, Clinical Diagnostic Systems: Technologies and Instrumentation, (4 June 2002); https://doi.org/10.1117/12.469776

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