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An automatic device for high-temporal resolution of the process of red blood sedimentation was designed. The position of the boundary between red blood and plasma may be registered each 30 sec in several pipettes simultaneously with +/- 10 mkm precision. Fractional rates of the boundary movement are deduced with high accuracy. Data are processed by a PC and presented as velocity-time curves and the curves describing time evolution of the boundary position. The results obtained with this equipment demonstrate non- monotonous character of the rate of red blood sedimentation and revealed several peculiarities of macroscopic stages and microkinetic of the process. Changes of biophysical-chemical state of blood related to changes in physiological state of a donor or under the action of different substances may result either in improving, or in worsening of studied parameters of blood sedimentation dynamics. A slight dilution of blood with saline in vitro leads as a rule to decreasing of sedimentation rate and improving of microkinetic parameters of the process of the red blood sedimentation. Adding of highly diluted hydrogen peroxide to blood samples of patients provides for the oxygenation of the system, and result in the improving of sedimentation dynamics: decreasing of average sedimentation rate and prolonging of macrokinetic states. The parameters of this reaction depend upon the metabolic potential of blood, the functional state of all its cellular and plasma elements, and in complex they reflect the physiological state of the individual Any changes in parameters of macro- and microkinetics may reflect the pattern of oxygen release- delivery-consumption in blood. ESR-graphy may give much more information in comparison to the routine ESR-test and allows to consider blood sedimentation not from the viewpoint of separate physico-chemical parameters, but treating it as a metabolically active system.
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