Monitoring the regional blood flow in the rat mesentery under the drug's effect by using laser speckle imaging

Haiying Cheng; Qingming Luo; Zheng Wang; Shaoqun Zeng; Jian Cen; Pengcheng Li

doi:10.1117/12.477779

8 July 2003 Monitoring of the regional blood flow in the rat mesentery under the drug's effect by using laser speckle imaging

Haiying Cheng, Qingming Luo, Zheng Wang, Shaoqun Zeng, Jian Cen, Pengcheng Li

Author Affiliations +

Proceedings Volume 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII; (2003) https://doi.org/10.1117/12.477779
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Monitoring the spatio-temporal characteristics of blood flow (BF) is crucial for physiological studies. At present, most optical techniques used for monitoring the BF utilize either the Doppler effect or the temporal statistics of time-varying speckle to measure the blood velocity at a point. If a map of blood velocity distribution is required, some form of scanning must be introduced, thus limiting the temporal and spatial resolution. Laser speckle imaging (LSI) technique could provide real-time spatially resolved BF images without the need for scanning by utilizing the spatial statistics of time-integrated speckle. In present paper, the regional blood flows in the rat mesentery under the effect of phentolamine with incremental concentration were monitored using LSI method. Our results showed that for arterioles, the vessels expanded and BF increased under the treatment with phentolamine of 1μg/ml. However, as the concentration increased, the BF decreased and dilation only happened at the concentration of 100μg/ml; For venules, no dilation was observed except for the case of 100μg/ml while BF decreased. These suggested that compared with the conventional methods, LSI could obtain the spatio-temporal dynamic of BF in the mesentery with high resolution without scan, providing a new approach in studying the microcirculation in the mesentery.

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Haiying Cheng, Qingming Luo, Zheng Wang, Shaoqun Zeng, Jian Cen, and Pengcheng Li "Monitoring of the regional blood flow in the rat mesentery under the drug's effect by using laser speckle imaging", Proc. SPIE 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, (8 July 2003); https://doi.org/10.1117/12.477779

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KEYWORDS

Blood circulation

Speckle

Laser speckle imaging

Velocity measurements

Blood

Spatial resolution

Charge-coupled devices

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