Laser-induced photoacoustic tomography for small animals

Xueding Wang; Yongjiang Pang; George Stoica; Lihong V. Wang

doi:10.1117/12.477788

1 July 2003 Laser-induced photoacoustic tomography for small animals

Xueding Wang, Yongjiang Pang, George Stoica, Lihong V. Wang

Proceedings Volume 4960, Biomedical Optoacoustics IV; (2003) https://doi.org/10.1117/12.477788
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Photoacoustic tomography, also called opto-acoustic tomography when laser excitation is used, is a novel medical imaging modality that combines the merits of both light and ultrasound. Here, we present our study of laser-induced photoacoustic tomography of organs of small animals. Pulses of 6.5 ns in width from an Nd:YAG laser at 532 nm or 1064 nm are employed to generate the distribution of thermoelastic expansion in the sample. A wide-band ultrasonic transducer that is non-focused in the imaging plane scans around the sample to realize a full-view detection of the imaged cross-section. A modified back-projection algorithm is applied to reconstruct the distribution of optical absorption inside the biological sample. Using optical energy depositions that fall below safe levels, tissue structures in ex-vivo rat kidneys and in-situ mouse brains covered by the skin and skull are imaged successfully with the high intrinsic optical contrast and the high spatial resolution of ultrasound.

Citation Download Citation

Xueding Wang, Yongjiang Pang, George Stoica, and Lihong V. Wang "Laser-induced photoacoustic tomography for small animals", Proc. SPIE 4960, Biomedical Optoacoustics IV, (1 July 2003); https://doi.org/10.1117/12.477788

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available