IR fiber optic sensing on biological tissue

Uwe Bindig; I. Gersonde; M. Meinke; Y. Becker; Gerhard Mueller

doi:10.1117/12.518753

13 October 2003 IR fiber optic sensing on biological tissue

Uwe Bindig, I. Gersonde, M. Meinke, Y. Becker, Gerhard Mueller

Proceedings Volume 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV; (2003) https://doi.org/10.1117/12.518753
Event: Saratov Fall Meeting 2002 Laser Physics and Photonics, Spectroscopy, and Molecular Modeling III; Coherent Optics of Ordered and Random Media III, 2002, Saratov, Russian Federation

Abstract

A diagnostic method is described to detect differences between diseased and normal tissue from bladder carcinoma by FTIR-microspectroscopy and fiber-optics methods. Regions of interest on 10 μm thin tissue sections were mapped using an IR-microscope in transmission mode. Afterwards the specimens were analyzed using standard pathological techniques. Quadratic discriminant as well as correlation analysis was applied for data analysis. IR optical fibers, not only allowed measurements to be made in the attenuated total reflectance (ATR)-mode but also absorption measurements to be carried out at a remote location. The IR-sensor is in contact with the sample which shows characteristic absorption lines. This method can be used to determine the absorption of a sample in a non-destructive manner. In this paper we report our efforts to develop a fiber-optic infrared sensor to differentiate between malignant and healthy tissue in vivo. Silver halide fibers and a special sensor tip were used for the ATR measurements on human tissue specimens. The results indicate that IR-spectrometry will be a useful tool for bio-diagnostics.

Citation Download Citation

Uwe Bindig, I. Gersonde, M. Meinke, Y. Becker, and Gerhard Mueller "IR fiber optic sensing on biological tissue", Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); https://doi.org/10.1117/12.518753

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KEYWORDS

Tissues

Tumors

Bladder

Tissue optics

Fiber optics

Absorption

Sensors

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