The mechanism of PDT-induced apoptosis

Xiongwei Cai; Timon Cheng-Yi Liu; Xin-Min Ding; Ying Gu M.D.; Fan-Guang Liu; Song-Hao Liu

doi:10.1117/12.546157

8 December 2003 The mechanism of PDT-induced apoptosis

Xiongwei Cai, Timon Cheng-Yi Liu, Xin-Min Ding, Ying Gu M.D., Fan-Guang Liu, Song-Hao Liu

Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546157
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China

Abstract

Photodynamic therapy (PDT) can induce apoptosis in many cancer cells in vitro and in tumors in vivo. Cells become more oxidation with PDT, and maintain differentiation and proliferation, go apoptosis and necrosis with the increase of reactive oxygen species (ROS) concentration. ROS can induce apoptosis through mitochondria by inhibiting respiration chain or oxidative phosphorylation or damaging mitochondrial membrane. ROS can initiate apoptosis through endoplamic reticulum(ER) by opening Ca²⁺ channel or starting unfold protein response (UPR). ROS can also induce apoptosis through Golgi by producing ganglioside GD3 by use of ceramide, which induces apoptosis by activating caspase-3, JNK and p38 MAPK. It can also induce apoptosis by activating Bip (mitochondria-dependant) or preocaspase-12 (mitochondria- independent) or inhibiting protein synthesizing. There are so complicated cross-talking among different signal pathways or organnells that we think PDT-induced apoptosis is mediated by multiplex pathways and excessive levels in a refined network.

Citation Download Citation

Xiongwei Cai, Timon Cheng-Yi Liu, Xin-Min Ding, Ying Gu M.D., Fan-Guang Liu, and Song-Hao Liu "The mechanism of PDT-induced apoptosis", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); https://doi.org/10.1117/12.546157

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