Analysis of cerebrospinal fluid for detection of ruptured cerebral aneurysm using spectrophotometry and signal processing techniques

Anindya Majumder; James Caffery Jr.; Prashant R. Bhadri; Fred Richard Beyette Jr.; Joseph F. Clark; Chad J. Morgan; Gail J. Pyne; Mario Zuccarello; Ed Jauch; Ken R. Wagner

doi:10.1117/12.538200

13 July 2004 Analysis of cerebrospinal fluid for detection of ruptured cerebral aneurysm using spectrophotometry and signal processing techniques

Anindya Majumder, James Caffery Jr., Prashant R. Bhadri, Fred Richard Beyette Jr., Joseph F. Clark, Chad J. Morgan, Gail J. Pyne, Mario Zuccarello, Ed Jauch, Ken R. Wagner

Author Affiliations +

Proceedings Volume 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV; (2004) https://doi.org/10.1117/12.538200
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

An accurate quantification of bilirubin in cerebrospinal fluid (CSF) will provide a simple, sensitive and rapid mechanism for detecting subarachnoid hemorrhage (SAH) and for its differentiation from a traumatic spinal tap. Derivative analysis of the spectrophotometric data provides a model for determining bilirubin in CSF where the primary contaminant is Methemoglobin. Bilirubin values are determined in the range 0-9mg/dl within a methemoglobin concentration of 4.6g/dl using the derivative analysis method. The algorithm is also implemented on test samples in which the bilirubin value is constant (4.6mg/dl) and the methemoglobin varies between 0-9g/dl. The performance of the derivative analysis method is compared to the modified minimum distance method developed in reference one. We suggest a combination of these methods for accurate bilirubin estimation in CSF/hemoglobin. This will provide the foundation for the development of a portable user friendly device for diagnosis of SAH.

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Anindya Majumder, James Caffery Jr., Prashant R. Bhadri, Fred Richard Beyette Jr., Joseph F. Clark, Chad J. Morgan, Gail J. Pyne, Mario Zuccarello, Ed Jauch, and Ken R. Wagner "Analysis of cerebrospinal fluid for detection of ruptured cerebral aneurysm using spectrophotometry and signal processing techniques", Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); https://doi.org/10.1117/12.538200

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