NIR laser tissue welding of in vitro porcine of cornea and sclera tissue

Richard B. Rosen M.D.; Howard E. Savage; Ramindra K. Halder; Uladzimir Kartazayeu; Tapan K. Gayen M.D.; Steven A. McCormick; Alvin Katz; Henry D. Perry; Robert R. Alfano

doi:10.1117/12.531019

13 July 2004 NIR laser tissue welding of in vitro porcine of cornea and sclera tissue

Richard B. Rosen M.D., Howard E. Savage, Ramindra K. Halder, Uladzimir Kartazayeu, Tapan K. Gayen M.D., Steven A. McCormick, Alvin Katz, Henry D. Perry, Robert R. Alfano

Author Affiliations +

Proceedings Volume 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV; (2004) https://doi.org/10.1117/12.531019
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

In this study, an NIR fiber laser with an eye safe wavelength of 1.455 μm was used to successfully weld in vitro porcine cornea and sclera tissue. The emission wavelength overlaps an absorption band of water. The laser system was used in combination with a motorized translational system and shutter to control the laser exposure on the tissue being welded. Different welding conditions were analyzed for the porcine cornea and sclera. The welded tissues were examined using histopathology and tensile strength analysis. The NIR welding technique provides strong, full thickness welds and does not require the use of extrinsic dyes, chromophores, or solders. The NIR laser system used in this study can effectively weld cornea and sclera tissue, and this laser tissue welding (LTW) methodology typically causes minimal disruption of tissue, and thus, avoids opacities and irregularities in the tissue which may result in decreased visual acuity.

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Richard B. Rosen M.D., Howard E. Savage, Ramindra K. Halder, Uladzimir Kartazayeu, Tapan K. Gayen M.D., Steven A. McCormick, Alvin Katz, Henry D. Perry, and Robert R. Alfano "NIR laser tissue welding of in vitro porcine of cornea and sclera tissue", Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); https://doi.org/10.1117/12.531019

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KEYWORDS

Tissues

Laser tissue interaction

Cornea

Sclera

Laser welding

Near infrared

Eye

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