Refractive index tomography of turbid media by bifocal optical coherence refractometry

Andrei V. Zvyagin; Sergey A. Alexandrov; K. K. M. B. Dilusha Silva; Timothy R. Hillman; Julian J. Armstrong; Takuya Tsuzuki; David D. Sampson

doi:10.1117/12.531272

1 July 2004 Refractive index tomography of turbid media by bifocal optical coherence refractometry

Andrei V. Zvyagin, Sergey A. Alexandrov, K. K. M. B. Dilusha Silva, Timothy R. Hillman, Julian J. Armstrong, Takuya Tsuzuki, David D. Sampson

Author Affiliations +

Proceedings Volume 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII; (2004) https://doi.org/10.1117/12.531272
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

We demonstrate tomographic imaging of the refractive index of turbid media using bifocal optical coherence refractometry (BOCR). The technique, which is a variant of optical coherence tomography, is based on measurement of the optical pathlength difference between two foci simultaneously present in the medium of interest. We describe a new method to axially shift the bifocal optical pathlength, thus, avoiding the need to physically relocate the objective lens or the sample during an axial scan, and present an experimental realization based on an adaptive liquid-crystal lens. We present experimental results, which demonstrate refractive index tomography of a range of turbid liquid samples, and also in situ living tissue. BOCR has potential for in vivo refractive index tomography of biological tissue.

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Andrei V. Zvyagin, Sergey A. Alexandrov, K. K. M. B. Dilusha Silva, Timothy R. Hillman, Julian J. Armstrong, Takuya Tsuzuki, and David D. Sampson "Refractive index tomography of turbid media by bifocal optical coherence refractometry", Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); https://doi.org/10.1117/12.531272

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