Spectroscopic monitoring of kidney tissue ischemic injury

Jason T. Fitzgerald; Andromachi P. Michalopoulou; Christoph Troppmann; Stavros G. Demos

doi:10.1117/12.529284

13 July 2004 Spectroscopic monitoring of kidney tissue ischemic injury

Jason T. Fitzgerald, Andromachi P. Michalopoulou, Christoph Troppmann, Stavros G. Demos

Proceedings Volume 5326, Optical Biopsy V; (2004) https://doi.org/10.1117/12.529284
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Noninvasive evaluation of tissue viability of donor kidneys used for transplantation is an issue that current technology is not able to address. In this work, we explore optical spectroscopy for its potential to assess the degree of ischemic damage in kidney tissue. We hypothesized that ischemic damage to kidney tissue will give rise to changes in its optical properties which in turn may be used to asses the degree of tissue injury. The experimental results demonstrate that the autofluorescence intensity of the injured kidney is decreasing as a function of time exposed to ischemic injury. Changes were also observed in the NIR light scattering intensities most probably arising from changes due to injury and death of the tissue.

Citation Download Citation

Jason T. Fitzgerald, Andromachi P. Michalopoulou, Christoph Troppmann, and Stavros G. Demos "Spectroscopic monitoring of kidney tissue ischemic injury", Proc. SPIE 5326, Optical Biopsy V, (13 July 2004); https://doi.org/10.1117/12.529284

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