Theoretical model on optical clearing of biological tissue with semipermeable chemical agents

Fujun Zhou; Ruikang K. Wang

doi:10.1117/12.531499

28 May 2004 Theoretical model on optical clearing of biological tissue with semipermeable chemical agents

Fujun Zhou, Ruikang K. Wang

Proceedings Volume 5330, Complex Dynamics, Fluctuations, Chaos, and Fractals in Biomedical Photonics; (2004) https://doi.org/10.1117/12.531499
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Quantitative analysis of biological tissue responding to chemical active agents (CAA) that osmotically transport across tissue poses a challenge task for modern biomedical technologies. It is known that the application of osmotically CAA to biotissue such as skin, muscle and gastrointestinal tracts can make the biological tissue transparent. Such osmotic action of agents to the biological tissue have not yet been understood or quantified in a way that degree of optical clearing to the tissue is predictive. We consider that optical properties of biological tissue are altered due to the changes of micro-structures and scattering constituents after CAA permeates into tissue. The changes of optical properties of biological tissue are due to the refractive indices matching between the particles (scatterers) with high refractive index and the ground substances leading to reduce scattering of tissue. The main reasons are that permeated CAA with higher refractive index than the ground substances of tissue makes the refractive index of ground substances of tissue higher by the enhancement of the permeated concentration. In this paper, we described a theoretical model based on the collimated transmittance changes of light penetrating fibrous tissue after the CAA administrates with different concentration.

Citation Download Citation

Fujun Zhou and Ruikang K. Wang "Theoretical model on optical clearing of biological tissue with semipermeable chemical agents", Proc. SPIE 5330, Complex Dynamics, Fluctuations, Chaos, and Fractals in Biomedical Photonics, (28 May 2004); https://doi.org/10.1117/12.531499

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available