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The main mechanism of penetration of the indocyanine green dye (ICG) (1) in upper human skin layers was determined for ICG water, ethanol and glycerol solutions. Some experiments with/without clearance of protection skin fat coat were carried out. We stained hand skin then we did several series of epidermis detachments by scotch. The spectra of stained skin were recorded by standard CARY-2415 spectrophotometer with an integrating sphere. The conclusion about the main mechanism of penetration of the ICG in human epidermis has been drown by analyze of the experiment results.
Tatyana V. Kulyabina andVyacheslav I. Kochubey
"In vivo investigation of interaction of indocyanine green solutions with human epidermis", Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); https://doi.org/10.1117/12.578990
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Tatyana V. Kulyabina, Vyacheslav I. Kochubey, "In vivo investigation of interaction of indocyanine green solutions with human epidermis," Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); https://doi.org/10.1117/12.578990