Study of complex micellar systems by static and dynamic light scattering

Boris N. Khlebtsov; Eugene M. Chumakov; Sergei V. Semyonov; Mikhail I. Chumakov; Nikolai G. Khlebtsov

doi:10.1117/12.568559

14 July 2004 Study of complex micellar systems by static and dynamic light scattering

Boris N. Khlebtsov, Eugene M. Chumakov, Sergei V. Semyonov, Mikhail I. Chumakov, Nikolai G. Khlebtsov

Proceedings Volume 5475, Saratov Fall Meeting 2003: Coherent Optics of Ordered and Random Media IV; (2004) https://doi.org/10.1117/12.568559
Event: Saratov Fall Meeting 2003, 2003, Saratov, Russian Federation

Abstract

The static and dynamic light scattering (DLS) methods were applied to study the thermodynamic properties and disperse structure of water+surfactant+solubilizer systems. It is supposed that such systems possess a micellar structure that can be used to develop new effective forms of veterinary drugs. For preparation of drugs (antibiotics) in micellar form, water solutions of the surfactant Cremafor-EL (CR) with the co-solvent dimethylacetamide (DMA) were used. To evaluate the stability of micellar solutions, we measured the light scattering intensity at 90 degrees as a function of temperature (20-80° C) in a water+CR+DMA system. The size distribution of micelles was determined by DLS measurements followed by DynaLS software processing. As thermodynamic characteristics of solutions, the so-called cloud point temperatures (CPT) and absolute instability temperatures (AIT) were used. Specifically, the CPT was determined as the intersection point of two linear fittings for scattering intensity vs temperature plots. AIT was determined using the inverse light scattering intensity data plotted vs temperature and then extrapolated to zero. The micelle-size distributions were measured for three types of surfactants (CR, Tween-80, and Tween-20), as well as for water+CR+DMA systems.

Citation Download Citation

Boris N. Khlebtsov, Eugene M. Chumakov, Sergei V. Semyonov, Mikhail I. Chumakov, and Nikolai G. Khlebtsov "Study of complex micellar systems by static and dynamic light scattering", Proc. SPIE 5475, Saratov Fall Meeting 2003: Coherent Optics of Ordered and Random Media IV, (14 July 2004); https://doi.org/10.1117/12.568559

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